The analysis of the published data on the ozone and NaCl interaction in aqueous solutions enables us to make the conclusion that during the treatment of these solutions with the ozone-oxygen gas mixture (in exposures, concentrations of ozone and NaCl as stated in papers) and the subsequent ozone decomposition therein, ozone does not interact neither with Na+ nor with Cl–; neither sodium hypochlorite nor any other chlorine-containing oxygen ions, nitrates and nitrites are formed. There are identified dissolved oxygen and ozone, and in the reaction of the latter with water there are produced free radicals, hydrogen peroxide (in a small amount), and hexagonal and small-molecular aqueous structures. Hexagonal aqueous molecules formed during the ozonation of aqueous solutions improve the transport across the cell membrane not only of electrolytes but probably of any other substances. Thus, Boyarinov and Sokolov have shown that when performing the ozonated bypass, more glucose is utilized by cells of the patient’s body than during the oxygenated bypass. Thus, dissolved ozone, free radicals, hydrogen peroxide, and hexagonal aqueous structures resulting from the bubbling of aqueous NaCl solutions with the ozone-oxygen mixture produce a therapeutic effect of the ozonated saline solution.